Mgr inż. Bożena Rolnik, pokój: 749
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Nota biograficzna:

2015 - rozpoczęcie studiów doktoranckich na kierunku Biocybernetyka i Inżynieria Biomedyczna

2015 - uzyskanie tytułu magistra z pracy poświęconej metodom analizy tła genetycznego radiowrażliwości w oparciu o informacje na temat copy number variation u osób rasy kaukaskiej.

2014 - uzyskanie tytułu inżyniera z pracy poświęconej wykorzystaniu siRNA w interferencji genów ze ścieżki sygnałowej NF-kB w komórkach raka jelita grubego.

Rozwiń/Zwiń

Zainteresowania naukowe:



Lista publikacji:

1. Grzegorz Mrukwa and Joanna Polanska: DiviK: Divisive intelligent K-means for hands-free unsupervised clustering in biological big data. BMC Bioinformatics, 2022, 23(1):538; doi: 10.1186/s12859-022-05093-z

2. Kurczyk A., Gawin M., Chekan M., Wilk Agata, Łakomiec Krzysztof, Mrukwa Grzegorz, Pietrowska M., Polańska Joanna, Fujarewicz Krzysztof, Widłak Piotr: Porównanie i klasyfikacja różnych typów histologicznych raka tarczycy w oparciu o dane pochodzące z eksperymentów obrazowania molekularnego mikromacierzy tkankowych
techniką MALDI-MSI, VII Śląskie Spotkania Naukowe, 29-30.05.2020, s.12-13

3. Agata Kurczyk, Marta Gawin, Mykola Chekan, Agata Wilk, Krzysztof Łakomiec, Grzegorz Mrukwa, Katarzyna Frątczak, Joanna Polanska, Krzysztof Fujarewicz, Monika Pietrowska, Piotr Widlak: Classification of thyroid tumors based on mass spectrometry imaging of tissue microarrays; a single-pixel approach. International Journal of Molecular Sciences, 2020, 21(17):6289; doi: 10.3390/ijms21176289

4. G. Mrukwa, K. Fratczak, M. Gawin, M. Chekan, M. Pietrowska, P. Widlak, J. Polanska, Biological Diversity or Numeric Artifact? MSI Data Clustering Robustness, European Molecular Imaging Meeting 2019, Glasgow, March 19-22, 2019

5. Nalepa J, Mrukwa G, Piechaczek S, Lorenzo PR, Marcinkiewicz M, Bobek-Billewicz B, Wawrzyniak P, Ulrych P, Szymanek J, Cwiek M, Dudzik W. Data Augmentation via Image Registration. In2019 IEEE International Conference on Image Processing (ICIP) 2019 Sep 22 (pp. 4250-4254). IEEE.

6. Mrukwa Grzegorz, Frątczak Katarzyna, Polańska Joanna: Hybrid clustering method for highly dimensional data,
2019, XII Symposium of Polish Bioinformatics Society, Kraków, September 19-21, 2019, s.47

7. Mrukwa G, Frątczak K, Polańska J: Hybrid Clustering Method for Highly Dimensional Data. 12th Symposium of the Polish Bioinformatics Society, 19-21 September 2019, Kraków, Poland

8. Katarzyna Bednarczyk, Marta Gawin, Mykola Chekan, Agata Kurczyk, Grzegorz Mrukwa, Monika Pietrowska, Joanna Polańska, Piotr Widłak: Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids, International Journal of Molecular Histology, 2019; 50(1):1-10, doi: 10.1007/s10735-018-9802-3

9. Bednarczyk K, Mrukwa G, Polańska J: Adaptive training set selection for classification in mass spectrometry imaging. 1st Summer School of the Malopolska Centre of Biotechnology, Zakopane 22-25 May, 2018

10. Katarzyna Bednarczyk, Marta Gawin, Mykola Chekan, Agata Kurczyk, Grzegorz Mrukwa, Monika Pietrowska, Joanna Polańska, Piotr Widłak: DISCRIMINATION OF NORMAL ORAL MUCOSA FROM ORAL CANCER BY MASS SPECTROMETRY IMAGING OF PROTEINS AND LIPIDS, Gliwickie Spotkania Naukowe, GSN 2018, 16-17.11.2018, Gliwice

11. Gawin M, Pietrowska M, Diehl HC, Mrukwa G, Kalinowska-Herok M, Chekan M, Elm J, Drążek G, Krawczyk A, Lange D, Polańska J, Henkel C, Widłak P: Obrazowanie molekularne MALDI-MSI w klasyfikacji raków tarczycy. III Zjazd Centrum Onkologii – Instytutu im. Marii Skłodowskiej-Curie. Perspektywy w onkologii molekularnej. 5-6.04.2018 Warszawa

12. Mrukwa Grzegorz, Pietrowska Monika, Widłak Piotr, Polańska Joanna: Investigation of molecular heterogeneity of head and neck cancer in MALDI-MSI preparations, 12th European Molecular Imaging Meeting - EMIM 2017, Cologne, Germany, 05-07.04.2017

13. Mrukwa Grzegorz, Joanna Polanska: Divisive intelligent k-means algorithm in support of identification of homogenous clusters in high dimensional data. Computational Approached in Precision Medicine, 2017, 27-28 July, Vienna, Austria - wykład

14. Mrukwa Grzegorz, Katarzyna Bednarczyk, Marta Gawin, Mykola Chekan, Monika Pietrowska, Piotr Widlak, Joanna Polanska: Do proteomic and lipidomic molecular images provide similar information on tumor heterogeneity? 5th International Conference of Mass Spectrometry Imaging Society OurConV, 25-28.09.2017, Doorn, Holandia

15. Wolny Michał, Grzegorz Mrukwa, Joanna Polańska: Co-registration of multimodal imaging data with ellipsis’ shape approximation. 5th International Conference of Mass Spectrometry Imaging Society OurConV, 25-28.09.2017, Doorn, Holandia

16. Chekan, M; Pietrowska, M; Diehl, HC; Mrukwa, G; Kalinowska-Herok, M; Gawin, M; Elm, J; Krawczyk, A; Lange, D; Meyer, HE; Polanska, J; Henkel, C; Widlak, P: Molecular profiles of thyroid cancer: Classification based on features of tissue revealed by mas spectrometry imaging; 29th European Congress of Pathology, September 2-6, 2017, Amsterdam, NL, VIRCHOWS ARCHIV, 471: S166-S166

17. Pietrowska M, Diehl HC, Mrukwa G, Kalinowska-Herok M, Gawin M, Chekan M, Elm J, Drazek G, Krawczyk A, Lange D, Meyer H, Polanska J, Henkel C, Widlak P (2017): Molecular profiles of thyroid cancer subtypes: classification based on features of tissue revealed by mass spectrometry imaging. 9th International Conference of Contemporary Oncology: Genome based precision immuno- and targeted therapy. Poznan March 22-24, 2017, Onkologia Współczesna, 21(S1):29

18. Wilgierz W., Kuchta D., Mrukwa G., Chekan M., Widłak P., Pietrowska M., Polańska J.: Genetic Algorithm in Training Set Selection for Tumor Segmentation Problem; Gliwickie Spotkania Naukowe 2017, 17-18.11.2017, Gliwice, Polska

19. Mrukwa G., Kuchta D., Pustelnik S., Wolny M., Babiak D., Gallus M., Wilgierz W., Gamrat M., Lisak R., Polańska J.: SPECTRE – a Web Service for Efficient Tumor Molecular Heterogeneity Assessment in MALDI MSI Data; Gliwickie Spotkania Naukowe 2017, 17-18.11.2017, Gliwice, Polska

20. Pietrowska Monika; Hanna Diehl; Grzegorz Mrukwa; Magdalena Kalinowska-Herok; Marta Gawin; Mykola Chekan; Julian Elm; Grzegorz Drazek; Anna Krawczyk; Dariusz Lange; Helmut E Meyer; Joanna Polanska; Corinna Henkel; Piotr Widlak: Molecular profiles of thyroid cancer subtypes: classification based on features of tissue revealed by mass spectrometry imaging. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2017, 1865(7):837-45, DOI: 10.1016/j.bbapap.2016.10.006

21. Mrukwa G, Drazek G, Pietrowska M, Widlak P, Polanska J: A novel divisive iK-means algorithm with region-driven feature selection as a tool for automated detection of tumour heterogeneity in MALDI IMS experiments. Bioinformatics and Biomedical Engineering, Lecture Notes in Computer Science, vol. 9656, pp. 113-124, 4th International Work-Conference on Bioinformatics and Biomedical Engineering IWBBIO 2016, Granada,Spain, 20-22.04.2016 ISBN 978-3-319-31744-1, DOI: 10.1007/978-3-319-31744-1_11

22. Mrukwa Grzegorz, Grzegorz Drazek, Monika Pietrowska, Piotr Widlak, Joanna Polanska: Divisive iK-means algorithm as a tool for ROI selection in the search for MALDI-MSI based molecular signature of thyroid cancer. 2nd Congress of Polish Biochemistry, Cell biology, Biotechnology and Bioinformatics Bio2016. 13-16.09.2016, Wrocław. Acta Biochimica Polonica, 2016, 63(S2):72

23. Mrukwa G, Sykacek P, Drążek G, Pietrowska M, Chekan M, Widłak P, Polańska J: Assessing feature transformations for clustering of MALDI-MSI data. OurCon IV, 4th Imaging Mass Spectrometry Conference, 17-21.10.2016, Ustroń

24. Widlak P, Pietrowska M, Diehl HC, Mrukwa G, Kalinowska-Herok M, Gawin M, Chekan M, Elm J, Drazek G, Krawczyk A, Lange D, Meyer HE, Polanska J, Henkel C: Classification of thyroid cancer subtypes based on features of tissue revealed by MALDI-MSI. OurCon IV, 4th Imaging Mass Spectrometry Conference, 17-21.10.2016, Ustroń

25. Polanska J, Mrukwa G, Drazek G, Krawczyk A, Chekan M, Pietrowska M, Widlak P: Gaussian Mixture modelling in MSI-based search for molecularly homogenous regions in cancer tissue. OurCon IV, 4th Imaging Mass Spectrometry Conference, 17-21.10.2016, Ustroń

26. Kalinowska-Herok M, Pietrowska M, Gawin M, Mrukwa G, Chekan M, Drazek G, Wierzgoń J, Polańska J, Widłak P. Molecular heterogeneity of oral squamous cell carcinoma and detection of signatures discriminating normal and cancerous epithelium by imaging mass spectrometry. Gliwickie Spotkania Naukowe 2016, 18-19.11.2016, Gliwice, Polska

27. Mrukwa G., Drazek G., Pietrowska M., Chekan M., Widlak P., Polanska J.: Iteracyjne zastosowanie deglomeracyjnego algorytmu iK-średnich do grupowania próbek MALDI-MSI pod kątem profilu molekularnego. III Śląskie Spotkania Naukowe, 3-4.06.2016, Dzierżno

28. Drazek G., Mrukwa G., Pietrowska M., Chekan M., Widlak P., Polanska J.: Wykrywanie sygnatury molekularnej raka nabłonka technikami obrazowania spektrometrii mas (MALDI-IMS). Śląskie Spotkania Naukowe, 3-4.06.2015, Dzierżno

29. Widlak P, Mrukwa G, Kalinowska M, Pietrowska M, Chekan M, Wierzgon J, Gawin M, Drazek G, Polanska J: Detection of molecular signatures of oral squamous cell carcinoma and normal epithelium – application of a novel methodology for unsupervised segmentation of imaging mass spectrometry data. Proteomics, 2016, 16(11-12):1613-21, DOI: 10.1002/pmic.201500458

30. Mrukwa G, Polanska J: Tuning k-means algorithm for detection of heterogenous regions in MSI samples. 9th Central and Eastern European Proteomics Conference CEEPC 2015, 15-18.06.2015 Poznań

31. Mrukwa G, Drazek G, Pietrowska M, Widlak P, Polanska J: Iterative clustering procedure for automated identification of peptide signature of molecularly heterogeneous tissue regions in tumor samples. 8th Symposium of the Polish Bioinformatics Society, 17-19 September 2015, Lublin, Poland

32. Pietrowska M, Kalinowska-Herok M, Gawin M, Chekan M, Wierzgon J, Drazek G, Mrukwa G, Polanska J, Widlak P: Molecular signatures for discrimination of normal epithelium from oral squamous cell carcinoma – study based on unsupervised analysis of imaging mass spectrometry. 3rd Imaging Mass Spectrometry Conference 2015, OurCon III, 27-29.10.2015, Pisa, Italy

33. Mrukwa G., Drazek G., Pietrowska M., Chekan M., Widlak P., Polanska J.: Novel ik-means algorithm comparison with PCA-based approach for determining heterogeneity in MALDI-MSI tumor samples. XIX Gliwice Scientific Meetings, Book of abstracts, p. 116. 20-21.11.2015, Gliwice, Poland

34. Widłak P, Pietrowska M, Kalinowska-Herok M, Gawin M, Chekan M, Wierzgoń J, Drążek G, Mrukwa G, Polanska J: Application of MALDI Imaging Mass Spectrometry for molecular characterization of oral squamous cell cancer and adjacent tissues. I Ogólnopolska Konferencja “Biomarkery w chorobach nowotworowych”, 9-10.10.2015, Wrocław